A Review of Colon Cancer Treatment using Photoactive Nanoparticles

This reviewed work on the development of photosensitive nanoparticles (NPs) based a photodegradable poly(o-nitrobenzyl acrylate) core (PNBA, hydrophobic and biocompatible polymer) dextran-derived shell (dextran is biodegradable water-soluble bacterial polysaccharide). First, methods for synthesizing PNBA-N3 were demonstrated by 1) single electron transfer radical polymerization (SET-LRP) o-nitrobenzyl acrylates then 2) introducing azide end functionalization. At same time, processes production DexAlkyne-15 bearing several alkyne groups hydrophilicity dextran also addressed. Such as can be reacted CuAAC (Cu(I)-azide-alkyne cycloaddition catalyst) chemically resulting in Dex-g-PNBA glycopolymers with different molecular parameters. Second, strategies producing NPs comparing two that characterized terms size, amount dextran, coat thickness, colloidal stability NaCl or cell culture medium, presence potent surfactant. On one hand, made nanodeposition exhibit high PNBA weight fractions (>40%). other produced evaporating emulsion to organic solvent using surfactant material. In this case, occurred situ (or not) at fluid/liquid interface during formulation NPs, “clicking” “non-clicking”. Finally, systematic study disorder ultraviolet irradiation according photolysis chains shown. To use smart drug delivery systems, studies have been shown loading Doxorubicin (DOX - an anti-cancer agent) into placement. Methods optimizing experimental conditions enhance DOX encapsulation are discussed.